The invention provides compositions and methods of use thereof, in conjunction with the treatment and prevention of kidney and ureteral stones and related urinary tract conditions in man or in animals. Specifically provided are compositions formulated for direct instillation into the kidney, bladder, ureter, and urethra of the urinary tract before, during, and after the treatment of kidney and ureteral stones, such as with lithotripsy to alleviate or reduce at least one symptom associated therewith, and to facilitate the stones passing through the kidney, bladder, ureter, urethra and urinary tract. Compositions of the invention can comprise therapeutic amounts of: chondroitin sulfate and hyaluronan, and optionally include N-acetyl D-glucosamine.