Invention Grant
- Patent Title: Methods and compositions for inhibiting the interaction of menin with MLL proteins
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Application No.: US15829604Application Date: 2017-12-01
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Publication No.: US10077271B2Publication Date: 2018-09-18
- Inventor: Jolanta Grembecka , Tomasz Cierpicki , Dmitry Borkin , Jonathan Pollock , Liansheng Li , Tao Wu , Jun Feng , Pingda Ren , Yi Liu , Szymon Klossowski
- Applicant: Kura Oncology, Inc. , The Regents of The University of Michigan
- Applicant Address: US CA San Diego US MI Ann Arbor
- Assignee: Kura Oncology, Inc.,The Regents of The University of Michigan
- Current Assignee: Kura Oncology, Inc.,The Regents of The University of Michigan
- Current Assignee Address: US CA San Diego US MI Ann Arbor
- Agency: Wilson Sonsini Goodrich & Rosati
- Priority: ARP20160100689 20160315
- Main IPC: C07D487/04
- IPC: C07D487/04 ; C07D473/34 ; C07D495/04 ; C07D491/048 ; C07D513/04 ; C07D519/00 ; C07D498/04
Abstract:
The present disclosure provides compositions and methods of use to inhibit the interaction of menin with MLL1, MLL2 and MLL-fusion oncoproteins. The compositions and methods of use are useful for the treatment of leukemia, solid cancers, diabetes and other diseases dependent on activity of MLL1, MLL2, MLL fusion proteins, and/or menin.
Public/Granted literature
- US20180105531A1 METHODS AND COMPOSITIONS FOR INHIBITING THE INTERACTION OF MENIN WITH MLL PROTEINS Public/Granted day:2018-04-19
Information query
