Invention Grant
- Patent Title: Antimicrobial peptide analogues derived from abalone (Haliotis discus) and antimicrobial pharmaceutical composition containing the same
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Application No.: US15364398Application Date: 2016-11-30
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Publication No.: US10077293B2Publication Date: 2018-09-18
- Inventor: Jung-Kil Seo , Ki-Young Lee , Sang-man Cho , In-Ah Lee
- Applicant: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, KUNSAN NATIONAL UNIVERSITY
- Applicant Address: KR Jeollabuk-Do
- Assignee: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, KUNSAN NATIONAL UNIVERSITY
- Current Assignee: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, KUNSAN NATIONAL UNIVERSITY
- Current Assignee Address: KR Jeollabuk-Do
- Agency: Duane Morris LLP
- Agent Gregory M. Lefkowitz; Jason M. Nolan
- Priority: KR10-2016-0154215 20161118
- Main IPC: C07K7/04
- IPC: C07K7/04 ; A61K38/04 ; A61Q17/00 ; A61Q19/00 ; A61Q19/10 ; C07K14/435 ; A61K8/64 ; A61K8/04 ; A23K20/147 ; A23L33/18 ; A61K38/00

Abstract:
The present disclosure relates to an antimicrobial peptide analog derived from abalone and an antimicrobial pharmaceutical composition containing the same. The antimicrobial peptide analog according to the present disclosure is designed based on hdMolluscidin which is a peptide derived from the gill of abalone and has been designed to be commercially viable by reducing the number of amino acids. Despite the reduced number of amino acids, the designed peptide analog exhibits very superior antimicrobial activity as well as high membrane permeability and low hemolytic activity.
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