Invention Grant
- Patent Title: Cysteine engineered antibodies and conjugates
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Application No.: US14851348Application Date: 2015-09-11
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Publication No.: US10077318B2Publication Date: 2018-09-18
- Inventor: Sunil Bhakta , Hans Erickson , Jagath R. Junutula , Katherine Kozak , Rachana Ohri , Thomas Pillow
- Applicant: Genentech, Inc.
- Applicant Address: US CA South San Francisco
- Assignee: Genentech, Inc.
- Current Assignee: Genentech, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: McNeill Baur PLLC
- Main IPC: C07K16/00
- IPC: C07K16/00 ; C07K16/32 ; C07K16/18 ; C07K16/28 ; C07K16/30 ; A61K51/10 ; C07K16/40 ; G01N33/58 ; A61K47/68 ; A61K39/00
Abstract:
Cysteine engineered antibodies comprising a free cysteine amino acid in the heavy chain or light chain are prepared by mutagenizing a nucleic acid sequence of a parent antibody and replacing one or more amino acid residues by cysteine to encode the cysteine engineered antibody; expressing the cysteine engineered antibody; and isolating the cysteine engineered antibody.
Public/Granted literature
- US20160130358A1 CYSTEINE ENGINEERED ANTIBODIES AND CONJUGATES Public/Granted day:2016-05-12
Information query
