A low energy sensor interface for a microcontroller unit (MCU) is provided. The sensor interface may include a sequencer in operative communication with one or more on-chip peripherals, a count and compare block in communication with one or more sensors and the sequencer, and a highly configurable decoder. The sequencer, the count and compare block and the decoder may be configured to autonomously analyze and collect sensor results using the on-chip peripherals in a low energy mode of operation without intervention from an associated central processing unit (CPU).