A speckle reduction apparatus (300) based on Mie scattering and perturbation drive is disclosed. The speckle reduction apparatus (300) comprises an optical reflective chamber (302) having an incident-light coupling device (301) and an exiting face (303) disposed thereon, and an optical device (308) which faces the incident-light coupling device (301) of the optical reflective chamber (302). The inner walls of the optical reflective chamber (302), except for the wall of light transparent exiting face (303), are mirror surfaces. The optical reflective chamber (302) is fully filled with transparent material (401) having medium particles (402) dispersed therein, which are able to induce Mie scattering of the incident laser. Either or both of the optical reflective chamber (302) and the optical device (308) are provided with a perturbation-sensitive device. The present invention may be implemented with reasonable and compact structure, achieving the following effects: low cost, effective speckle reduction, high laser efficiency, stability, safety, and uniform light intensity.