Optimized positioning paths for multi-axis CNC machining can be generated based on the machine tool kinematics, machine axes travel limits, machine axis velocity and acceleration limits, and machine positioning methodologies. Machine axes travel limits and machine positioning methodologies are incorporated in order to ensure that the developed positioning paths do not violate machine axes travel limitations. Multi-axis positioning paths are developed to avoid collisions with dynamically changing in-process stock and other surroundings, including fixtures and both moving and non-moving components of the machine. Positioning tool path customizations give the user the flexibility to apply safety based constraints to the automatically generated tool paths. The disclosed automatic positioning path planning and optimization methods are used to develop a process for part manufacturing using CNC machining in order to reduce the manufacturing cycle time.