A protection circuit and a method for a high voltage switching regulator is presented. A power supply comprising a switching converter for providing an output voltage is provided. The switching converter is comprised of a first power switch coupled to a second power switch via a switching node, and a driver coupled to the first and second power switches. There is a protection circuit comprised of a first isolation switch coupled to a second isolation switch and a first driver for driving the first isolation switch, and a second driver for driving the second isolation switch. The circuit and method may comprise turning off both the first isolation switch and the second isolation switch when the first power switch and the second power switch are both turned off. This isolates a low voltage domain from a high voltage domain. This prevents current leakages from occurring during switching dead times.