In a method, system, or computer-readable medium for an ontology-based request/reply service (RRS), different request/reply services (RRS) are hosted, each different RRS dedicatedly represents a different unique service and provides connections from client to server instance of the unique service, each different RRS accessed by client and server instances through a same independent communication layer (ICL). A request from the client is received through the ICL. The RRS is determined by the unique service indicated in the request, and instantiated dynamically as needed, according to an individual RRS ontology which establishes a syntactical and semantical framework dedicated to the unique service. The request is routed to the RRS and then through a server instance of the unique service to process the request; then a response is returned to the client to satisfy the request. It provides transport connectivity and mutual communication between combinations of clients, different RRSs, and server instances.