A method, system and a Common Service Entity (CSE) for sending a Machine-to-Machine (M2M) application request are provided. The method includes that: after receiving a request sent by an M2M application, a local CSE sends the request of the M2M application to a target CSE according to a value of a request type or according to a value of delay time for request sending and a value of a request type in the request, wherein the request sent by the M2M application includes one or more of the following parameters: an application identifier, the delay time for request sending and the request type.