A technique for handling cache-inhibited operations in a data processing system includes receiving, at a topology specific replicated bus unit, a cache-inhibited (CI) operation that is scope limited. The replicated bus unit determines whether an address associated with the CI operation matches an address for the replicated bus unit. In response to the address associated with the CI operation matching the address for the replicated bus unit, the replicated bus unit processes the CI operation based on the scope being limited to that of the replicated bus unit. In response to the address associated with the CI operation not matching the address for the replicated bus unit, the replicated bus unit ignores the CI operation.