According to one embodiment, a computerized method is directed to neutralizing callback malware. This method involves intercepting an incoming message from a remote source directed to a compromised endpoint device. Next, a first portion of information within the incoming message is substituted with a second portion of information. The second portion of information is designed to mitigate operability of the callback malware. Thereafter, the modified incoming message, which includes the second portion of the information, is returned to the compromised endpoint device.