Invention Grant
- Patent Title: Composition of dexibuprofen transdermal hydrogel
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Application No.: US14824787Application Date: 2015-08-12
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Publication No.: US10085939B2Publication Date: 2018-10-02
- Inventor: Jeffrey Stuart Bergman , Sampathkumar Devarajan , Selvakumar Ramalingam , Anandsenthil Vel Palanisamy
- Applicant: Strides Shasun Limited
- Applicant Address: IN
- Assignee: Strides Shasun Limited
- Current Assignee: Strides Shasun Limited
- Current Assignee Address: IN
- Main IPC: A61K9/06
- IPC: A61K9/06 ; A61K31/192 ; A61K9/00 ; A61K47/02 ; A61K47/12 ; A61K47/38 ; A61K47/10 ; A61K47/18 ; A61K47/32

Abstract:
Stable non-alcoholic transdermal hydrogel of dexibuprofen was prepared by using a simple manufacturing process, and the experimental trials showed that the pH modifying agent, antioxidant and water miscible solvent are the essential excipients to obtain stable non-alcoholic transdermal hydrogel of dexibuprofen. The dexibuprofen hydrogel prepared using carbopol as a gelling polymer produced an opaque gel, whereas hydrogel prepared using hyroxypropyl methylcellulose (HPMC) as a gelling polymer produced a transparent gel. There was no significant changes observed with respect to physical description, pH, assay and particularly to the related substance values when the hydrogels were subjected to the stability study at accelerated condition (40° C./75% RH) for 3 months in laminated tubes.
Public/Granted literature
- US20150342879A1 COMPOSITION OF DEXIBUPROFEN TRANSDERMAL HYDROGEL Public/Granted day:2015-12-03
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