Invention Grant
- Patent Title: Lamin A, an activator of longevity/anti-aging SIRT1 protein
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Application No.: US14687553Application Date: 2015-04-15
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Publication No.: US10086039B2Publication Date: 2018-10-02
- Inventor: Zhongjun Zhou , Baohua Liu
- Applicant: THE UNIVERSITY OF HONG KONG
- Applicant Address: CN Hong Kong
- Assignee: THE UNIVERSITY OF HONG KONG
- Current Assignee: THE UNIVERSITY OF HONG KONG
- Current Assignee Address: CN Hong Kong
- Agency: Saliwanchik, Lloyd & Eisenschenk
- Main IPC: A61K38/16
- IPC: A61K38/16 ; A61K38/17 ; C12Q1/37 ; C12Q1/34 ; A61K31/05 ; G01N33/573
Abstract:
In one embodiment, the present invention provides methods of modulating the deacetylase activity of SIRT1 in one or more cell by modifying the binding affinity of lamin A to SIRT1 via one or more interaction modifying compound. In another embodiment, the present invention provides methods of screening SIRT1-activating/inhibiting compounds based on the interaction between lamin A and SIRT1 proteins and SIRT1-activating property of lamin A. In another embodiment, the present invention provides uses of SIRT1-activating compounds to treat patient(s) suffering from metabolic and/or aging-related degenerative diseases, and uses of SIRT1-inhibiting compounds to treat human malignancies.
Public/Granted literature
- US20160067305A1 Lamin A, An Activator of Longevity/Anti-Aging SIRT1 Protein Public/Granted day:2016-03-10
Information query
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