- Patent Title: Efficient protein expression in vivo using modified RNA (MOD-RNA)
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Application No.: US14009351Application Date: 2012-03-12
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Publication No.: US10086043B2Publication Date: 2018-10-02
- Inventor: Kenneth R. Chien , Leon M. Ptaszek , Oi-Lan Lui , Lior Zangi , Wataru Ebina , Derrick J. Rossi
- Applicant: Kenneth R. Chien , Leon M. Ptaszek , Oi-Lan Lui , Lior Zangi , Wataru Ebina , Derrick J. Rossi
- Applicant Address: US MA Boston US MA Boston
- Assignee: THE GENERAL HOSPITAL CORPORATION,CHILDREN'S MEDICAL CENTER CORPORATION
- Current Assignee: THE GENERAL HOSPITAL CORPORATION,CHILDREN'S MEDICAL CENTER CORPORATION
- Current Assignee Address: US MA Boston US MA Boston
- Agency: Nixon Peabody LLP
- International Application: PCT/US2012/028802 WO 20120312
- International Announcement: WO2012/138453 WO 20121011
- Main IPC: A61K38/18
- IPC: A61K38/18 ; A01K67/027 ; A61K48/00 ; C12N15/11 ; A61K31/7115 ; A61K31/4745 ; A61K31/513 ; A61K31/517 ; A61K31/519 ; A61K31/555 ; A61K31/7068 ; A61K33/24 ; A61L31/10 ; A61L31/16
Abstract:
Aspects of the invention described herein relate to synthetic, modified RNAs and their use in vivo to modulate gene expression. Aspects of the invention further relate to the use of these synthetic, modified RNAs in myocytes, cardiomyoctes, and tumors.
Public/Granted literature
- US20140073687A1 EFFICIENT PROTEIN EXPRESSION IN VIVO USING MODIFIED RNA (MOD-RNA) Public/Granted day:2014-03-13
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