- Patent Title: Indocyanine compound, synthesis method and purification method thereof, diagnostic composition using the indocyanine compound, and device for measuring biokinetics and device for visualizing circulation using the diagnostic composition
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Application No.: US15438047Application Date: 2017-02-21
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Publication No.: US10086090B2Publication Date: 2018-10-02
- Inventor: Katsunori Teranishi , Hitoshi Hirata , Tetsuya Arai
- Applicant: NATIONAL UNIVERSITY CORPORATION MIE UNIVERSITY , NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY
- Applicant Address: JP Tsu-shi JP Nagoya-shi
- Assignee: NATIONAL UNIVERSITY CORPORATION MIE UNIVERSITY,NATIONAL UNIVERSITY CORPORATON NAGOYA UNIVERSITY
- Current Assignee: NATIONAL UNIVERSITY CORPORATION MIE UNIVERSITY,NATIONAL UNIVERSITY CORPORATON NAGOYA UNIVERSITY
- Current Assignee Address: JP Tsu-shi JP Nagoya-shi
- Agency: Oblon, McClelland, Maier & Neustadt, L.L.P.
- Priority: JP2010-017255 20100128; JP2010-132923 20100610
- Main IPC: A61B5/00
- IPC: A61B5/00 ; A61B8/00 ; A61B10/00 ; A61K49/00 ; C08B37/16 ; C09B23/01 ; C09B23/08 ; A61B5/0205 ; A61B5/026 ; A61B5/20 ; A61M5/00 ; C09B67/00 ; A61B5/0275

Abstract:
The present invention aims at providing a novel indocyanine compound solving problems of conventionally used indocyanine green, such as solubility in water or physiological saline, a synthesis method and a purification method thereof, and a diagnostic composition including the novel indocyanine compound. Further, provided are a method for evaluating biokinetics of the novel indocyanine compound and a device for measuring biokinetics, and a method and a device for visualizing circulation of fluid such as blood in a living body, which utilize the diagnostic composition. Also, found are a novel indocyanine compound in which a hydrophobic moiety in a near-infrared fluorescent indocyanine molecule is included in a cavity of a cyclic sugar chain cyclodextrin to cover the hydrophobic moiety in the indocyanine molecule with the glucose, and a synthesis method and a purification method thereof. Furthermore, found are a method for fluorescence-imaging an organ other than liver by intravenous administration, a method for evaluating biokinetics of the novel indocyanine compound, a device for measuring biokinetics, and a method and a device for visualizing circulation of fluid such as blood in a living body, utilizing the diagnostic composition including the novel indocyanine compound.
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