The present invention is directed to a method of making a self-sealing pneumatic tire, the tire having a tread width and a radially innermost surface having a residue deposited thereon, comprising the steps of: activating a laser to generate laser radiation; directing a pulse of laser radiation to impinge on an area of the innermost surface, the pulse of radiation having a pulse width and a fluence sufficient to remove at least part of the residue in the area to form a cleaned area; repeating the step of directing the pulse of radiation sequentially over the innermost surface to form a sequence of cleaned areas, the sequence of cleaned areas defining a stripe, the stripe following a continuous nonlinear path extending at least one circumference about the inner surface, the stripe having a stripe width W2; applying a bead of sealant in a continuous bead path extending at least one circumference about the inner surface, the bead of sealant at least partially overlaying the stripe. The invention is further directed to as such a self-sealing pneumatic tire.