A hood guiding system for a work vehicle may include first and second walls positioned within an engine compartment of the work vehicle. The system may also include a hood configured to extend in a crosswise direction of the work vehicle between a first side and a second side so as to least partially cover the engine compartment. Additionally, the system may include a first guide component coupled to the hood at or adjacent to its first side and a second guide component coupled to the hood at or adjacent to its second side. When the hood is moved from an opened position to a closed position, the first and second guide components may be configured to contact outer surfaces of the first and second walls, respectively, to guide the hood towards the closed position.