Invention Grant
- Patent Title: Process for the preparation of halo-substituted benzenes
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Application No.: US15516110Application Date: 2015-10-08
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Publication No.: US10087126B2Publication Date: 2018-10-02
- Inventor: Helmars Smits , Paul Knochel , Thomas Klatt , Matthias Becker
- Applicant: SYNGENTA PARTICIPATIONS AG
- Applicant Address: CH Basel
- Assignee: SYNGENTA PARTICIPATIONS AG
- Current Assignee: SYNGENTA PARTICIPATIONS AG
- Current Assignee Address: CH Basel
- Priority: EP14188740 20141014
- International Application: PCT/EP2015/073217 WO 20151008
- International Announcement: WO2016/058895 WO 20160421
- Main IPC: C07C17/25
- IPC: C07C17/25 ; C07C17/383 ; C07C17/35 ; C07C17/38 ; C07C17/013

Abstract:
The invention relates to a process for the preparation of compound of formula (I) wherein R1 is halogen and R2 is halogen or hydrogen; comprising a) reacting the compound of formula (II) in an aprotic organic solvent in the presence of an aprotic polar co-solvent with a magnesium amide base followed by a halogenating agent, to the compound of formula I wherein R1 is halogen and R2 is hydrogen, and b) reacting the compound of formula (I), wherein R1 is chloro and R2 is hydrogen, in an aprotic organic solvent in the presence of an aprotic polar co-solvent with a magnesium amide base followed by a halogenating agent to a compound of formula I, wherein R1 is chloro and R2 is halogen.
Public/Granted literature
- US20170297981A1 PROCESS FOR THE PREPARATION OF HALO-SUBSTITUTED BENZENES Public/Granted day:2017-10-19
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