Invention Grant
- Patent Title: Pyrazole compound
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Application No.: US15491130Application Date: 2017-04-19
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Publication No.: US10087146B2Publication Date: 2018-10-02
- Inventor: Izumi Sasaki , Tomohiro Toyoda , Hidefumi Yoshinaga , Itaru Natsutani , Yoko Takahashi
- Applicant: Sumitomo Dainippon Pharma Co., Ltd.
- Applicant Address: JP Osaka
- Assignee: Sumitomo Dainippon Pharma Co., Ltd.
- Current Assignee: Sumitomo Dainippon Pharma Co., Ltd.
- Current Assignee Address: JP Osaka
- Agency: Wenderoth, Lind & Ponack, L.L.P.
- Priority: JP2010-160705 20100715
- Main IPC: C07D231/20
- IPC: C07D231/20 ; C07D231/38 ; C07D405/06 ; C07D493/08 ; C07D231/18

Abstract:
The present invention relates to a novel serotonin reuptake inhibitor which also exhibits 5-HT2C antagonistic action (antidepressive and anxiolytic effects), in particular, 5-HT2C inverse agonistic action comprising Compound (1): or a pharmaceutically acceptable salt thereof wherein R1, R2, R3 and R4 are independently hydrogen or C1-6 alkyl etc.; R5 is C4-7 alkyl or —(CR8R9)r-E; R6, R7, R8 and R9 are independently hydrogen, fluorine or C1-6 alkyl; A is C6-10 aryl or heteroaryl etc.; r is 1, 2, 3 or 4; E is C3-8 cycloalkyl or C6-10 aryl etc.; L is oxygen, sulfur or —NR10—; n is 1, 2 or 3; R10 is hydrogen or C1-6 alkyl etc.; and X is hydrogen or halogen etc.
Public/Granted literature
- US20170217902A1 PYRAZOLE COMPOUND Public/Granted day:2017-08-03
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