Invention Grant
- Patent Title: Selective histone deacetylase 8 inhibitors
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Application No.: US14763013Application Date: 2014-01-24
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Publication No.: US10087149B2Publication Date: 2018-10-02
- Inventor: Aaron Beaty Beeler , John A. Porco, Jr. , Oscar J. Ingham , James E. Bradner
- Applicant: TRUSTEES OF BOSTON UNIVERSITY , DANA-FARBER CANCER INSTITUTE, INC.
- Applicant Address: US MA Boston US MA Boston
- Assignee: TRUSTEES OF BOSTON UNIVERSITY,DANA-FARBER CANCER INSTITUTE, INC.
- Current Assignee: TRUSTEES OF BOSTON UNIVERSITY,DANA-FARBER CANCER INSTITUTE, INC.
- Current Assignee Address: US MA Boston US MA Boston
- Agency: Nixon Peabody LLP
- International Application: PCT/US2014/012968 WO 20140124
- International Announcement: WO2014/116962 WO 20140731
- Main IPC: C07D249/06
- IPC: C07D249/06 ; A61K31/4192 ; A61K45/06
Abstract:
Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of histone deacetylase 8 (HDAC8). Also described herein are methods of using such HDAC8 inhibitors, alone and in combination with other compounds, for treating diseases or conditions that benefit from inhibition of HDAC8 activity.
Public/Granted literature
- US20150352079A1 SELECTIVE HISTONE DEACETYLASE 8 INHIBITORS Public/Granted day:2015-12-10
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