Invention Grant
- Patent Title: Piperidine derivative and preparation method and pharmaceutical use thereof
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Application No.: US15736898Application Date: 2016-05-27
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Publication No.: US10087191B2Publication Date: 2018-10-02
- Inventor: Shanghai Yu , Fanglong Yang , Lei Chen , Jingjing Yan , Xiqian Zhang , Zhichao Xie , Lingxiang Chen , Mingxun He
- Applicant: Jiangsu Hengrui Medicine Co., Ltd. , Shanghai Hengrui Pharmaceutical Co., Ltd.
- Applicant Address: CN Lianyungang, Jiangsu CN Shanghai
- Assignee: Jiangsu Hengrui Medicine Co., Ltd.,Shanghai Hengrui Pharmaceutical Co., Ltd.
- Current Assignee: Jiangsu Hengrui Medicine Co., Ltd.,Shanghai Hengrui Pharmaceutical Co., Ltd.
- Current Assignee Address: CN Lianyungang, Jiangsu CN Shanghai
- Agency: Panitch Schwarze Belisario & Nadel LLP
- Priority: CN201510334700 20150616; CN201510954294 20151218
- International Application: PCT/CN2016/083636 WO 20160527
- International Announcement: WO2016/202161 WO 20161222
- Main IPC: C07D217/04
- IPC: C07D217/04 ; C07D491/048 ; A61K31/472 ; A61K31/4355 ; C07D491/056 ; C07D217/16 ; C07D471/04 ; C07D401/10 ; C07D413/10 ; C07D405/12 ; C07D495/04
Abstract:
The present invention relates to a piperidine derivative and the preparation method and a pharmaceutical use thereof. In particular, the present invention relates to the piperidine derivative as shown by general formula (I) and the preparation method thereof and a pharmaceutical composition containing the same, and the use thereof as an estrogen receptor modulator in the treatment of estrogen receptor mediated or dependent diseases or conditions, the diseases preferably being breast cancer. In the abstract, the definition of each substituent of the general formula (I) is the same as that in the description.
Public/Granted literature
- US20180170943A1 PIPERIDINE DERIVATIVE AND PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF Public/Granted day:2018-06-21
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