Invention Grant
- Patent Title: Antiviral compounds, a process for their preparation, and their use for treating viral infections
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Application No.: US15568692Application Date: 2016-04-27
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Publication No.: US10087209B2Publication Date: 2018-10-02
- Inventor: Piet Herdewijn , Steven De Jonghe , Shrivinas Dumbre , Chao Liu
- Applicant: KU LEUVEN RESEARCH & DEVELOPMENT
- Applicant Address: BE Leuven
- Assignee: KU LEUVEN RESEARCH & DEVELOPMENT
- Current Assignee: KU LEUVEN RESEARCH & DEVELOPMENT
- Current Assignee Address: BE Leuven
- Agency: Duane Morris LLP
- Agent Gregory M. Lefkowitz; Jason M. Nolan
- Priority: GB1507181.4 20150428; GB1601277.5 20160125
- International Application: PCT/EP2016/059394 WO 20160427
- International Announcement: WO2016/174081 WO 20161103
- Main IPC: C07H19/10
- IPC: C07H19/10 ; C07H19/20 ; A61K31/7076 ; A61K45/06 ; A61P35/00 ; A61K31/708 ; A61K31/7072 ; A61K31/7068 ; A61P31/20
Abstract:
The present invention relates to novel pro-drugs of L-2′-deoxythreose nucleoside phosphonates, such as phosphoramidate, phosphorodiamidate and phospho-diester pro-drugs. The invention also relates to a process for preparing these novel prodrugs of nucleoside phosphonates. The invention also relates to the use of these novel phosphonate-modified nucleosides to treat or prevent viral infections and their use to manufacture a medicine to treat or prevent viral infections, particularly infections with viruses belonging to the HBV family.
Public/Granted literature
- US20180105552A1 NOVEL ANTIVIRAL COMPOUNDS, A PROCESS FOR THEIR PREPARATION, AND THEIR USE FOR TREATING VIRAL INFECTIONS Public/Granted day:2018-04-19
Information query
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