Invention Grant
- Patent Title: Murine anti-NY-ESO-1 T cell receptors
-
Application No.: US15267285Application Date: 2016-09-16
-
Publication No.: US10087230B2Publication Date: 2018-10-02
- Inventor: Maria R. Parkhurst , Richard A. Morgan , Steven A. Rosenberg , Shannon Faith Rosati
- Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Applicant Address: US DC Washington
- Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee Address: US DC Washington
- Agency: Leydig, Voit & Mayer
- Main IPC: C07K14/725
- IPC: C07K14/725 ; G01N33/574 ; C07K7/06 ; C07K7/08 ; C07K16/18 ; C07K16/28 ; C07K16/30 ; A61K38/00
Abstract:
The invention provides an isolated or purified T cell receptor (TCR) having antigenic specificity for NY-ESO-1. Also provided are related polypeptides, proteins, nucleic acids, recombinant expression vectors, isolated host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions. The invention further provides a method of detecting the presence of cancer in a mammal and a method of treating or preventing cancer in a mammal using the inventive TCRs or related materials.
Public/Granted literature
- US20170029483A1 MURINE ANTI-NY-ESO-1 T CELL RECEPTORS Public/Granted day:2017-02-02
Information query
