Invention Grant
- Patent Title: Humanization of rabbit antibodies using a universal antibody framework
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Application No.: US14965488Application Date: 2015-12-10
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Publication No.: US10087244B2Publication Date: 2018-10-02
- Inventor: Leonardo Jose Borras , David Urech
- Applicant: ESBATech, an Alcon Biomedical Research Unit LLC
- Applicant Address: CH Shlieren
- Assignee: ESBATech, an Alcon Biomedical Research Unit LLC
- Current Assignee: ESBATech, an Alcon Biomedical Research Unit LLC
- Current Assignee Address: CH Shlieren
- Agent Jason J. Derry
- Main IPC: C07K14/465
- IPC: C07K14/465 ; C07K16/18 ; C07K16/22 ; C07K16/24 ; A61K39/395 ; C07K16/30 ; C07K16/46 ; A61K47/68
Abstract:
The present invention relates to an universal antibody acceptor framework and to methods for grafting non-human antibodies, e.g., rabbit antibodies, using a universal antibody acceptor framework. Antibodies generated by the methods of the invention are useful in a variety of diagnostic and therapeutic applications.
Public/Granted literature
- US20160096903A1 HUMANIZATION OF RABBIT ANTIBODIES USING A UNIVERSAL ANTIBODY FRAMEWORK Public/Granted day:2016-04-07
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