Systems and methods are described for conductively heated vacuum-based drying of portable electronic devices. For example, a portable electronic device that has been exposed to excessive liquid is placed inside a drying chamber. The drying chamber is closed and a drying routine commences. During the drying routine, the chamber is pressurized to a vacuum level sufficient to gasify liquids inside the device, and the device is conductively heated at least to replace latent heat of vaporization lost during the pressurization. Some embodiments include techniques relating to payment processing, monitoring and feedback control, decontamination, and/or other functionality.