The present ergonomic mouse is shaped for being held by a hand generally in an upright or handshake position. It has a thumb side for engaging a thumb and a finger side for engaging the fingers. Buttons are arranged at a front portion of the finger side. A forward-facing transverse edge and a backward facing transverse edge extend across adjacent buttons and define there between a concave transverse channel for receiving the fingertips. Forward-facing transverse edge provides grip when pulling the mouse backward, and backward-facing transverse edge provides grip when pushing the mouse forward. The channel prevents the mouse from slipping within the hand during maneuvering and enables precise control with a relaxed grip.