This disclosure relates to systems, media, and methods for quantifying and monitoring exercise parameters and/or motion parameters, including performing data acquisition, analysis, and providing scientifically valid, clinically relevant, and/or actionable diagnostic feedback. Disclosed embodiments may receive real-time sensor data from a motion sensor or sensors mounted on a user and/or equipment while a user performs a test motion. Disclosed embodiments may also calculate a test motion profile based on the real-time sensor data, the test motion profile describing a multi-dimensional representation of the test motion performed by the user or computed motion profiles. Disclosed embodiments may include comparing the test motion profile to a template motion profile to determine a deviation amount for the test motion profile indicating how the test motion deviated from the template motion profile. Still further embodiments may correlate test motion profiles over time with health indicators.