The present disclosure provides a three-dimensional point cloud model reconstruction method and a device. The method comprises: 1) sampling and WLPO-consolidating an input point set to generate an initial surface point set, copying the initial surface point set as an initial position of an interior skeleton point set, to establish a correspondence relation between surface points and skeleton points; 2) moving points in the interior skeleton point set inwards along a direction opposite to a normal vector thereof, to generate interior points; 3) using a self-adaptive anisotropic neighborhood as a regularization term to perform an optimization of the interior points, and generating skeleton points; 4) performing a consolidation and completion of the initial surface point set using the skeleton points, to generate consolidated surface points; 5) reconstructing a three-dimensional point cloud model according to the skeleton points, the surface points and the correspondence relation between the surface points and the skeleton points.