Invention Grant
- Patent Title: Hypotonic microbicidal formulations and methods of use
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Application No.: US15120852Application Date: 2015-08-27
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Publication No.: US10092509B2Publication Date: 2018-10-09
- Inventor: Katharina Maisel , Craig W. Hendrix , Laura Ensign , Edward Fuchs , Richard Cone , Justin Hanes
- Applicant: The Johns Hopkins University
- Applicant Address: US MD Baltimore
- Assignee: The Johns Hopkins University
- Current Assignee: The Johns Hopkins University
- Current Assignee Address: US MD Baltimore
- Agency: Pabst Patent Group LLP
- International Application: PCT/US2015/017120 WO 20150827
- International Announcement: WO2015/127368 WO 20150827
- Main IPC: A61K9/00
- IPC: A61K9/00 ; A61K31/52

Abstract:
Hypotonic microbicidal compositions including an antimicrobial, such as an antiviral compound, and a pharmaceutically acceptable carrier in a solution formulation having hypotonic osmolarity have been developed for administration rectally to the gastrointestinal mucosa. In a preferred embodiment for use in preventing or decreasing HIV infection, the microbiocidal is tenofovir, or a prodrug or derivative thereof. The formulations may include additional agents such as surfactants to enhance cleansing, buffers, or preservatives. Polymers may be included for osmolarity as well as comfort.
Public/Granted literature
- US20170119662A1 HYPOTONIC MICROBICIDAL FORMULATIONS AND METHODS OF USE Public/Granted day:2017-05-04
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