Invention Grant
- Patent Title: Methods for enhancing hematopoietic stem/progenitor cell engraftment
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Application No.: US14706560Application Date: 2015-05-07
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Publication No.: US10092599B2Publication Date: 2018-10-09
- Inventor: Leonard I. Zon , Pulin Li
- Applicant: CHILDREN'S MEDICAL CENTER CORPORATION
- Applicant Address: US MA Boston
- Assignee: Children's Medical Center Corporation
- Current Assignee: Children's Medical Center Corporation
- Current Assignee Address: US MA Boston
- Agency: Nixon Peabody LLP
- Agent David S. Resnick; Ravinderjit S. Braich
- Main IPC: A01N65/00
- IPC: A01N65/00 ; A61K35/28 ; A61K31/192 ; A61K31/196 ; A61K31/19 ; A61K31/23 ; A61K31/336 ; A61K31/662 ; A61K45/06 ; A61K35/12
Abstract:
Described herein are methods for enhancing engraftment of hematopoietic stem and progenitor cells using compounds identified using a zebrafish model of hematopoietic cell engraftment. The compounds can be used to treat hematopoietic stem cells ex vivo prior to transplantation of the cells. Alternatively, the compounds can be administered to an individual undergoing cell transplantation.
Public/Granted literature
- US20150246075A1 METHODS FOR ENHANCING HEMATOPOIETIC STEM/PROGENITOR CELL ENGRAFTMENT Public/Granted day:2015-09-03
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