Invention Grant
- Patent Title: Competitive PPAR-gamma antagonists
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Application No.: US15500330Application Date: 2015-07-14
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Publication No.: US10093628B2Publication Date: 2018-10-09
- Inventor: Tilo Knape , Andreas Von Knethen , Michael John Parnham , Manfred Schubert-Zsilavecz , Mario Wurglics , Daniel Flesch
- Applicant: FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
- Applicant Address: DE Munich
- Assignee: FRAUNHOFER-GESELLSCHAFT ZUR FÖDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
- Current Assignee: FRAUNHOFER-GESELLSCHAFT ZUR FÖDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
- Current Assignee Address: DE Munich
- Agency: Hamre, Schumann, Mueller & Larson, P.C.
- Priority: EP14179761 20140804; EP14187969 20141007
- International Application: PCT/EP2015/066085 WO 20150714
- International Announcement: WO2016/020156 WO 20160211
- Main IPC: A61K31/47
- IPC: A61K31/47 ; A61K31/192 ; C07D215/233 ; C07C57/50 ; A61K45/06
Abstract:
The present invention pertains to a new compound E)-2-(5-((4-methoxy-2-(trifluoromethyl)quinolin-6-yl)methoxy)-2-((4-(trifluoromethyl) benzyl)oxy)-benzylidene) hexanoic acid (MTTB), and its derivatives. The compounds of the invention are useful as selective peroxisome proliferator-activated receptor gamma (PPARγ) antagonists and are indicated for the use in the treatment of immune related diseases such as systemic inflammation, sepsis and septic shock.
Public/Granted literature
- US20170210711A1 COMPETITIVE PPAR-GAMMA ANTAGONISTS Public/Granted day:2017-07-27
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