Invention Grant
- Patent Title: Multitarget hedgehog pathway inhibitors and uses thereof
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Application No.: US14898955Application Date: 2014-06-25
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Publication No.: US10093642B2Publication Date: 2018-10-09
- Inventor: Bruno Botta , Alberto Gulino , Maurizio Botta , Mattia Mori , Lucia Di Marcotullio , Paola Infante , Francesca Ghirga , Sara Toscano , Cinzia Ingallina , Romina Alfonsi
- Applicant: UNIVERSITA' DEGLI STUDI DI SIENA , UNIVERSITA' DEGLI STUDI DI ROMA “LA SAPIENZA”
- Applicant Address: IT Rome (RM) IT Siena (SI)
- Assignee: UNIVERSITÀ DEGLI STUDI DI ROMA “LA SAPIENZA”,UNIVERSITA DEGLI STUDI DI SIENA
- Current Assignee: UNIVERSITÀ DEGLI STUDI DI ROMA “LA SAPIENZA”,UNIVERSITA DEGLI STUDI DI SIENA
- Current Assignee Address: IT Rome (RM) IT Siena (SI)
- Agency: Lucas & Mercanti, LLP
- Priority: ITRM2013A0366 20130625
- International Application: PCT/EP2014/063449 WO 20140625
- International Announcement: WO2014/207069 WO 20141231
- Main IPC: C07D311/34
- IPC: C07D311/34 ; A61K9/00 ; A61K9/127 ; A61K45/06 ; A61K31/352 ; A61K31/121 ; A61K31/343 ; A61K31/35
Abstract:
The present invention concerns compounds that selectively inhibit the activity of the Hedgehog (Hh) pathway, their preparation and uses thereof. The compounds of the present invention are useful in treating Hh-dependent tumors, such as medulloblastoma (MB).
Public/Granted literature
- US20160368886A1 MULTITARGET HEDGEHOG PATHWAY INHIBITORS AND USES THEREOF Public/Granted day:2016-12-22
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