Invention Grant
- Patent Title: Azaspiro derivatives as TRPM8 antagonists
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Application No.: US15125615Application Date: 2015-03-16
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Publication No.: US10093678B2Publication Date: 2018-10-09
- Inventor: Yuji Shishido , Masashi Ohmi , Kazuo Ando
- Applicant: RaQualia Pharma Inc.
- Applicant Address: JP Aichi
- Assignee: RaQualia Pharma Inc.
- Current Assignee: RaQualia Pharma Inc.
- Current Assignee Address: JP Aichi
- Agency: Wenderoth, Lind & Ponack, L.L.P.
- International Application: PCT/JP2015/001454 WO 20150316
- International Announcement: WO2015/136947 WO 20150917
- Main IPC: C07D491/056
- IPC: C07D491/056 ; C07D403/12 ; C07D401/14 ; C07D405/14 ; C07D413/14 ; A61K31/427 ; A61K31/437 ; C07D401/12 ; C07D403/06 ; C07D403/10 ; C07D403/14 ; C07D409/10 ; C07D409/14 ; C07D413/06 ; C07D417/06 ; C07D417/10 ; C07D417/14 ; C07D471/04 ; C07D487/04 ; C07D263/52 ; C07D491/048 ; A61K31/4178 ; A61K31/422 ; A61K31/435 ; C07D235/06 ; A61K31/4184 ; A61K31/423 ; A61K31/4355 ; A61K31/4439 ; A61K31/444 ; A61K31/4545 ; A61K31/4709 ; A61K31/4725 ; A61K31/497 ; A61K31/498 ; A61K31/4985 ; A61K31/501 ; A61K31/502 ; A61K31/5025 ; A61K31/506 ; A61K31/517 ; A61K31/519 ; A61K31/538 ; C07D235/02 ; C07D413/10
Abstract:
The present invention relates to azaspiro derivatives of the formula (I) or a pharmaceutically acceptable salt thereof or a prodrug thereof, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders which are mediated via the TRPM8 receptor.
Public/Granted literature
- US20170002016A1 AZASPIRO DERIVATIVES AS TRPM8 ANTAGONISTS Public/Granted day:2017-01-05
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