Invention Grant
- Patent Title: Factor XIa inhibitors
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Application No.: US15305421Application Date: 2015-04-21
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Publication No.: US10093683B2Publication Date: 2018-10-09
- Inventor: Yeon-Hee Lim , Zhuyan Guo , Amjad Ali , Scott D. Edmondson , Weiguo Liu , Gioconda V. Gallo-Etienne , Heping Wu , Ying-Duo Gao , Andrew W. Stamford , Younong Yu , Nancy J. Kevin , Rajan Anand , Deyou Sha , Santhosh F. Neelamkavil , Zahid Hussain , Puneet Kumar , Remond Moningka , Joseph L. Duffy , Jiayi Xu , Yu Jiang , Anjan Chakrabarti , Hiroki Sone
- Applicant: Merck Sharp & Dohme Corp.
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Nicole M. Beeler; John C. Toadaro
- International Application: PCT/US2015/026774 WO 20150421
- International Announcement: WO2015/164308 WO 20151029
- Main IPC: C07D498/20
- IPC: C07D498/20 ; C07F9/6561 ; C07D487/10 ; C07D498/10 ; C07D471/10
Abstract:
The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more compounds of Formula (I), and methods for using the compounds of Formula (I) for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
Public/Granted literature
- US20170044183A1 FACTOR XIa INHIBITORS Public/Granted day:2017-02-16
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