Invention Grant
- Patent Title: Peptide having efficacy for remedying hypopigmentation and inhibiting adipogenesis, and use of same
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Application No.: US15307587Application Date: 2014-11-21
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Publication No.: US10093698B2Publication Date: 2018-10-09
- Inventor: Yong Ji Chung , Eun Mi Kim , Eung Ji Lee , Kyoung Mi Cho
- Applicant: CAREGEN CO., LTD.
- Applicant Address: KR Anyang-si
- Assignee: CAREGEN CO., LTD.
- Current Assignee: CAREGEN CO., LTD.
- Current Assignee Address: KR Anyang-si
- Agency: Clark & Elbing LLP
- Agent Susan M. Michaud
- Priority: KR10-2014-0057189 20140513
- International Application: PCT/KR2014/011273 WO 20141121
- International Announcement: WO2015/174599 WO 20151119
- Main IPC: A61K38/08
- IPC: A61K38/08 ; A61K38/00 ; C07K7/06

Abstract:
A peptide formed from the amino acid sequence of SEQ ID NO: 1 or SEQ ID NO: 2 shows a melanogenesis increment activity and an adipogenesis inhibitory activity. The peptide, by increasing phosphorylation of MITF, which is a transcription factor for increasing a tyrosinase expression, and CREB for increasing an MITF expression, consequently increases a tyrosinase expression and ultimately increases melanin synthesis. The peptide, by reducing the amount of fat accumulated inside a cell and reducing expressions of perilipin and PPARγ, which contribute to adipogenic mechanism, ultimately inhibits adipogenesis. A composition for remedying or treating melanin hypopigmentation, a composition comprising the peptide, and a pharmaceutical composition for treating or preventing obesity, are provided.
Public/Granted literature
- US20170051014A1 PEPTIDE HAVING EFFICACY FOR REMEDYING HYPOPIGMENTATION AND INHIBITING ADIPOGENESIS, AND USE OF SAME Public/Granted day:2017-02-23
Information query
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