Invention Grant
- Patent Title: Heterodimers of IL-15 and IL-15R alpha to increase thymic output and to treat lymphopenia
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Application No.: US15485093Application Date: 2017-04-11
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Publication No.: US10093710B2Publication Date: 2018-10-09
- Inventor: George N. Pavlakis , Barbara K. Felber , Antonio Valentin , Cristina Bergamaschi
- Applicant: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES
- Applicant Address: US DC Washington
- Assignee: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES
- Current Assignee: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES
- Current Assignee Address: US DC Washington
- Agent David A. Carpenter
- Main IPC: C12N15/62
- IPC: C12N15/62 ; C07K14/54 ; C07K14/715 ; C12N15/09 ; A61K38/00 ; C12N5/07 ; C12P21/02 ; C12N15/113
Abstract:
The present invention provides method for promoting the maturation and export of T cells from thymic tissue by contacting the thymic tissue with supraphysiological levels of interleukin (IL)-15. The present invention also provides methods for preventing, alleviating, reducing, and/or inhibiting lymphopenia or peripheral depletion of lymphocytes in a patient in need thereof by administering to the patient IL-15.
Public/Granted literature
- US20170226174A1 HETERODIMERS OF IL-15 AND IL-15R ALPHA TO INCREASE THYMIC OUTPUT AND TO TREAT LYMPHOPENIA Public/Granted day:2017-08-10
Information query
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