Invention Grant
- Patent Title: Methods for treating cancer
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Application No.: US14902966Application Date: 2014-07-03
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Publication No.: US10093716B2Publication Date: 2018-10-09
- Inventor: Henning Walczak , Silvia Von Karstedt
- Applicant: UCL BUSINESS PLC
- Applicant Address: GB London
- Assignee: UCL BUSINESS PLC
- Current Assignee: UCL BUSINESS PLC
- Current Assignee Address: GB London
- Agency: Andrus Intellectual Property Law, LLP
- Priority: GB1312155.3 20130705
- International Application: PCT/GB2014/052025 WO 20140703
- International Announcement: WO2015/001345 WO 20150108
- Main IPC: A61K38/19
- IPC: A61K38/19 ; A61K39/395 ; C07K14/705 ; C07K16/24 ; C07K16/28 ; A61K38/17 ; G01N33/574 ; C07K14/525 ; C07K14/715 ; A61K39/00
Abstract:
The present invention relates to methods and materials for treating an individual with KRAS-mutated cancer or a cancer in which ROCK is inhibited independently of mutated KRAS. The invention is based on the prevention or disruption of the binding of TRAIL-Receptor to its ligand, TRAIL, in vivo, for example by use of an agent that neutralizes TRAIL and/or a the TRAIL-Receptor (such TRAIL-R2) and/or diminishes TRAIL/TRAIL-Receptor activity, thereby reducing cancer cell transformation, migration and metastasis, prolonging survival of patients.
Public/Granted literature
- US20160297865A1 METHODS FOR TREATING CANCER Public/Granted day:2016-10-13
Information query
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