Invention Grant
- Patent Title: Hepatic stellate cell precursors and methods of isolating same
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Application No.: US15205908Application Date: 2016-07-08
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Publication No.: US10093895B2Publication Date: 2018-10-09
- Inventor: Hiroshi Kubota , Lola M. Reid
- Applicant: University of North Carolina at Chapel Hill
- Applicant Address: US NC Chapel Hill
- Assignee: The University of North Carolina at Chapel Hill
- Current Assignee: The University of North Carolina at Chapel Hill
- Current Assignee Address: US NC Chapel Hill
- Agency: Foley & Lardner LLP
- Agent Gilberto M. Villacorta; Natasha Iyer
- Main IPC: C12N5/02
- IPC: C12N5/02 ; C12N5/077 ; C12N5/00 ; C12N5/071
Abstract:
The present invention relates to precursor cells to hepatic stellate cells, compositions comprising same and methods of isolating same. The surface antigenic profile of the precursors is MHC class Ia negative, ICAM-1+, VCAM-1+, β3-integrin+. In addition to expression of these surface markers, the cells also express the intracellular markers desmin, vimentin, smooth muscle α-actin, nestin, hepatocyte growth factor, stromal derived factor-1α and Hlx homeobox transcriptional factor.
Public/Granted literature
- US20170152472A1 HEPATIC STELLATE CELL PRECURSORS AND METHODS OF ISOLATING SAME Public/Granted day:2017-06-01
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