An interlocking construction block system comprising a family of blocks that interlock along three axes, including a left/right axis, a front/back axis, and an up/down axis. The family of blocks are self-aligning and do not require skilled labor or mortar to create a structure of any length, width, height, or shape. Each block comprises a specific geometry that allows all blocks in the family to interlock in a woven pattern that not only locks the blocks in place but also allows even distribution of structural weights and stresses. The disclosed blocks can be manufactured in different sizes to conform to any building code requirement and to create wall lengths to a one-inch measurement. The blocks may comprise channel openings to allow for plumbing, electrical, and structural reinforcements in the structure and may each be reinforced with an internal mesh cage.