A ferrule includes a body surrounding a bore that provides a fluid path along a central axis between a first end and a second end of the ferrule. The body includes a conical section configured for forming a sealing interface with a fitting in which the ferrule may be inserted and a sealing interface with a tube that may be inserted in the ferrule bore. The conical section includes collapse zones configured to collapse in a direction along the central axis in response to axial compression of the ferrule against the fitting. The collapse zones mitigate crushing of the ferrule against the tube. The collapse zones may be provided by a sealing region at the nose of the ferrule and annular grooves on the ferrule.