Systems and methods for systems and methods for image sticking avoidance in Organic Light-Emitting Diode (OLED) displays. In an illustrative, non-limiting embodiment, an Information Handling System (IHS) may include an OLED screen and a controller coupled to the OLED screen, where the controller is configured to: generate at least one current histogram matrix for a current frame; compare the at least one current histogram matrix against at least one previous histogram matrix generated for a previous frame; and enter a screen protection mode of operation in response to the comparison indicating that the at least one current histogram matrix is different from the at least one previous histogram matrix by an amount equal to or smaller than a threshold.