Methods and apparatus for providing adaptive grounding in mixed-signal electronic dies, circuits, modules, or other devices. In one example a module in which adaptive grounding is implemented includes a substrate having disposed thereon a plurality of signal contacts and a ground connection, and a mixed-signal die disposed on the substrate and including a signal section and a control section, the signal section having a plurality of radio frequency components each connected to a respective one of the plurality of signal contacts on the substrate by a corresponding signal connector, and the control section having at least two ground paths that selectively connect the control section to the ground connection on the substrate and which are physically spaced apart from one another, the mixed-signal die further including at least two switches, each operable to selectively connect one of the ground paths to the ground connection.