A self-calibrating transceiver includes a baseband processor, a receiver chain comprising an amplifier and a digital front end (DFE), and a transmitter chain, and a calibration control state machine. The state machine stores amplifier gain steps and is in communication with the transmitter chain, the receiver chain, and the baseband processor. The state machine can set a receiver chain frequency at a predefined frequency and set a transmitter chain frequency to be offset relative to the receiver chain frequency. For each of the amplifier gain steps, the state machine can set a gain of the receiver chain and set a power of the transmitter chain. The baseband processor can measure an RSSI and transmit the measured RSSI to the state machine. The state machine can determine a digital gain compensation value based on the one or more measured RSSIs and apply the determined digital gain compensation value.