A system and method for interfacing and controlling multiple musical instrument effects modules and pedals on a common platform. The system includes: a system processor; a backplane coupled with the system processor; a plurality of musical instrument effects modules removably inserted into the backplane, a plurality of musical instrument effects pedals removably inserted into the backplane via looper channels, each of the plurality of musical instrument effects modules and pedals including an audio input signal interface and an audio output signal interface, at least one of the musical instrument effects modules including a programmable potentiometer and/or programmable switch to modify an audio output signal; and a user interface configured to enable a user to apply a desired setting on the programmable potentiometer of the musical instrument effects modules via the system processor and the backplane: and a user interface configured to enable a user to reorder the musical effects signal path by dragging and dropping a module or pedal icon to a desired position among a plurality of icons thus electrically reordering the effects signal path.