Example methods are provided for a first endpoint to transfer a first data set and a second data set to a second endpoint using a multipath connection. The method may comprise detecting the first data set and the second data set from an application executing on the first endpoint for transfer to the second endpoint. The method may comprise, in response to determination that in-order transfer is not required for the first data set and the second data set, establishing a first subflow of a multipath connection with the second endpoint to send the first data set and establishing a second subflow of the multipath connection to send the second data set. The method may further comprise sending the first data set on the first subflow and the second data set on the second subflow to the second endpoint.