A therapeutic device for applying pressure to a portion of a wearer's body is provided. The device includes a flexible enclosure formed from a flexible material and configured to enclose at least a portion of the wearer's body, thereby forming a cavity between an inner surface of the enclosure and the body. The device also includes at least one port extending through the flexible enclosure for accessing the cavity; and a fluid evacuation pump in fluid communication with the cavity. The device is configured such that, upon actuation of the pump, the flexible enclosure transitions from a relaxed position to a compressed position, in which the flexible enclosure exerts a compression force against the wearer's body. Optionally, the flexible enclosure defines a cross sectional area, wherein the cross sectional area in the relaxed position is greater than the cross sectional area in the compressed position.