Several embodiments of memory devices and systems with command and control access are described herein. In one embodiment, a memory device includes a controller having a processor and a memory component operably coupled to the processor. The controller is configured to receive at least one command and control (C2) packet from a remote computer associated with a device vendor. The C2 packet includes a request for the controller to perform a restricted command, and a vendor signature. The memory component stores instructions executable by the processor to determine if the vendor signature is valid and to direct the controller to perform the restricted command if the vendor signature is determined to be valid.