Invention Grant
- Patent Title: Mesylic acid salt of acylthiourea compound, crystal of the same, and process for producing these
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Application No.: US15570021Application Date: 2016-04-28
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Publication No.: US10143688B2Publication Date: 2018-12-04
- Inventor: Ayako Sato
- Applicant: TAIHO PHARMACEUTICAL CO., LTD.
- Applicant Address: JP Chiyoda-ku
- Assignee: TAIHO PHARMACEUTICAL CO., LTD.
- Current Assignee: TAIHO PHARMACEUTICAL CO., LTD.
- Current Assignee Address: JP Chiyoda-ku
- Agency: Oblon, McClelland, Maier & Neustadt, L.L.P.
- Priority: JP2015-092815 20150430
- International Application: PCT/JP2016/063413 WO 20160428
- International Announcement: WO2016/175305 WO 20161103
- Main IPC: C07D215/48
- IPC: C07D215/48 ; A61K31/47 ; A61P35/00 ; A61K9/00 ; A61K31/17

Abstract:
An object of the present invention is to provide a salt compound of 4-(2-fluoro-4-(3-(2-phenylacetyl)thioureido)phenoxy)-7-methoxy-N-methylquinoline-6-carboxamide, which is useful as an antitumor agent, and crystal of the salt. The salt and the crystal are excellent in terms of solubility, stability, and peroral absorbability and can be mass-produced. The present invention relates to: a mesylic acid salt of 4-(2-fluoro-4-(3-(2-phenylacetyl)thioureido)phenoxy)-7-methoxy-N-methylquinoline-6-carboxamide; and the mesylic acid salt including a crystal which gives an X-ray powder diffraction spectrum having characteristic peaks at specific diffraction angles.
Public/Granted literature
- US20180161317A1 MESYLIC ACID SALT OF ACYLTHIOUREA COMPOUND, CRYSTAL OF THE SAME, AND PROCESS FOR PRODUCING THESE Public/Granted day:2018-06-14
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