An all-attitude human-machine interaction vehicle is disclosed. The all-attitude human-machine interaction vehicle includes a vehicle body and two wheels coupled with the vehicle body. The vehicle body includes a support frame, a pedal disposed on the support frame, a first position sensor, and a controller. The first position sensor is configured to detect attitude information of a user standing on the pedal. The controller is configured to drive the wheels to rotate according to the attitude information. The all-attitude human-machine interaction vehicle can detect attitude information of a user standing on the pedal and drive the wheels to rotate according to the attitude information. Furthermore, sitting or even standing on one foot, the user can still manipulate the all-attitude human-machine interaction vehicle, which further adds to the fun in manipulation.